Ontology highlight
ABSTRACT:
SUBMITTER: Bertin S
PROVIDER: S-EPMC4843825 | biostudies-other | 2014 Nov
REPOSITORIES: biostudies-other
Nature immunology 20141005 11
TRPV1 is a Ca(2+)-permeable channel studied mostly as a pain receptor in sensory neurons. However, its role in other cell types is poorly understood. Here we found that TRPV1 was functionally expressed in CD4(+) T cells, where it acted as a non-store-operated Ca(2+) channel and contributed to T cell antigen receptor (TCR)-induced Ca(2+) influx, TCR signaling and T cell activation. In models of T cell-mediated colitis, TRPV1 promoted colitogenic T cell responses and intestinal inflammation. Furth ...[more]