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An expanded role for mTORC1 in autophagy.


ABSTRACT: Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of mTORC1. This finding has provided new insight into the roles of mTORC1 in cellular membrane processes and cancer.

SUBMITTER: Kim YM 

PROVIDER: S-EPMC4845164 | biostudies-other | 2016 Jan

REPOSITORIES: biostudies-other

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