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Tailoring combinatorial cancer therapies to target the origins of adaptive resistance.


ABSTRACT: The development of resistance to chemotherapy is a critical yet poorly understood phenomenon driving cancer-related deaths. We recently reported a study that explored the origins of adaptive chemotherapy resistance. During this investigation we unexpectedly discovered that inherent vulnerabilities were unmasked, creating temporal targets for rational combinations of established drugs.

SUBMITTER: Goldman A 

PROVIDER: S-EPMC4845182 | biostudies-other | 2016 Jan

REPOSITORIES: biostudies-other

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