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Δ113p53/Δ133p53 converts P53 from a repressor to a promoter of DNA double-stand break repair.


ABSTRACT: In response to DNA damage, p53 (TP53, best known as p53) is quickly activated leading to cell cycle arrest or apoptosis to ensure genomic integrity; however, this represses DNA double-strand break (DSB) repair. Our recent work revealed that Δ113p53/Δ133p53 protein is accumulated at a later stage upon DNA DSB stress to switch p53 signaling from repression to promotion of DNA DSB repair.

SUBMITTER: Gong L 

PROVIDER: S-EPMC4845190 | biostudies-other | 2016 Jan

REPOSITORIES: biostudies-other

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