Unknown

Dataset Information

0

The double life of RIPK1.


ABSTRACT: We have recently identified receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) as an oncogenic driver in melanoma in addition to its well-established role in controlling cell survival and death. Our studies show that RIPK1 promotes melanoma cell proliferation through a positive feedback loop of NFKB1-BIRC2/BIRC3-RIPK1 powered by autocrine tumor necrosis factor.

SUBMITTER: Jin L 

PROVIDER: S-EPMC4845194 | biostudies-other | 2016 Jan

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC3252837 | biostudies-other
| S-EPMC8292240 | biostudies-literature
| S-EPMC5834731 | biostudies-literature
| S-EPMC6744433 | biostudies-literature
| S-EPMC9932129 | biostudies-literature
| S-EPMC8837545 | biostudies-literature
| S-EPMC9554302 | biostudies-literature
| S-EPMC10499419 | biostudies-literature
| S-EPMC6748150 | biostudies-literature
| S-EPMC11325021 | biostudies-literature