The double life of RIPK1.
Ontology highlight
ABSTRACT: We have recently identified receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) as an oncogenic driver in melanoma in addition to its well-established role in controlling cell survival and death. Our studies show that RIPK1 promotes melanoma cell proliferation through a positive feedback loop of NFKB1-BIRC2/BIRC3-RIPK1 powered by autocrine tumor necrosis factor.
SUBMITTER: Jin L
PROVIDER: S-EPMC4845194 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
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