Modulation of hepcidin to treat iron deregulation: potential clinical applications.
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ABSTRACT:
SUBMITTER: Blanchette NL
PROVIDER: S-EPMC4849272 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Publications
Modulation of hepcidin to treat iron deregulation: potential clinical applications.
Blanchette Nicole L NL Manz David H DH Torti Frank M FM Torti Suzy V SV
Expert review of hematology 20151215 2
The secreted peptide hormone hepcidin regulates systemic and local iron homeostasis through degradation of the iron exporter ferroportin. Dysregulation of hepcidin leads to altered iron homeostasis and development of pathological disorders including hemochromatosis, and iron loading and iron restrictive anemias. Therapeutic modulation of hepcidin is a promising method to ameliorate these conditions. Several approaches have been taken to enhance or reduce the effects of hepcidin in vitro and in v ...[more]
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