KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-?B Signaling Pathway.
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ABSTRACT:
SUBMITTER: Kong Y
PROVIDER: S-EPMC4860895 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Publications
KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway.
Kong Yanjie Y Li Fubin F Nian Yin Y Zhou Zhongmei Z Yang Runxiang R Qiu Ming-Hua MH Chen Ceshi C
Theranostics 20160412 6
Triterpenoids extracted from Cimicifuga foetida have been reported to inhibit cancer by inducing cell cycle arrest and apoptosis. In this study, KHF16 (24-acetylisodahurinol-3-O-β-D-xylopyranoside), a cycloartane triterpenoid isolated from the rhizomes of C. foetida, showed potent anti-cancer activity in multiple ERα/PR/HER2 triple-negative breast cancer (TNBC) cell lines. KHF16 significantly induces cell cycle G2/M phase arrest and apoptosis in both MDA-MB-468 and SW527 TNBC cell lines. KHF16 r ...[more]
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