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Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells.

ABSTRACT: Neural stem cells (NSCs) bear characteristics for proliferation, migration and differentiation into three main neural cell type(s): neurons, astrocytes and/or oligodendrocytes. Formylpeptide receptors (Fprs), belonging to the family of G protein-coupled chemoattractant receptors, have been detected on neurons in the central nervous system (CNS). Here, we report that Fpr1 and Fpr2 are expressed on NSCs as detected with immunohistochemistry, RT-PCR and WB assays. In addition, Fpr1 and Fpr2 promoted NSC migration through F-actin polymerization and skewed NSC differentiation to neurons. Our study demonstrates a unique role of Fpr1 and Fpr2 in NSCs and opens a novel window for cell replacement therapies for brain and spinal cord injury.

SUBMITTER: Wang G

PROVIDER: S-EPMC4865803 | biostudies-other | 2016

REPOSITORIES: biostudies-other

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Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells.

Wang Guan G Zhang Liang L Chen Xingxing X Xue Xin X Guo Qiaonan Q Liu Mingyong M Zhao Jianhua J

Scientific reports 20160513

Neural stem cells (NSCs) bear characteristics for proliferation, migration and differentiation into three main neural cell type(s): neurons, astrocytes and/or oligodendrocytes. Formylpeptide receptors (Fprs), belonging to the family of G protein-coupled chemoattractant receptors, have been detected on neurons in the central nervous system (CNS). Here, we report that Fpr1 and Fpr2 are expressed on NSCs as detected with immunohistochemistry, RT-PCR and WB assays. In addition, Fpr1 and Fpr2 promote ...[more]

PMID: 27173446

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