Ontology highlight
ABSTRACT:
SUBMITTER: Petropoulos S
PROVIDER: S-EPMC4868821 | biostudies-other | 2016 May
REPOSITORIES: biostudies-other
Petropoulos Sophie S Edsgärd Daniel D Reinius Björn B Deng Qiaolin Q Panula Sarita Pauliina SP Codeluppi Simone S Plaza Reyes Alvaro A Linnarsson Sten S Sandberg Rickard R Lanner Fredrik F
Cell 20160407 4
Mouse studies have been instrumental in forming our current understanding of early cell-lineage decisions; however, similar insights into the early human development are severely limited. Here, we present a comprehensive transcriptional map of human embryo development, including the sequenced transcriptomes of 1,529 individual cells from 88 human preimplantation embryos. These data show that cells undergo an intermediate state of co-expression of lineage-specific genes, followed by a concurrent ...[more]