The potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1.
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ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC4875467 | biostudies-other | 2012 May
REPOSITORIES: biostudies-other
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The potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1.
Wang Shuai S Long Jing J Zheng Chun-fu CF
Protein & cell 20120428 5
Herpes simplex virus type 1 (HSV-1) is a common human pathogen causing cold sores and even more serious diseases. It can establish a latent stage in sensory ganglia after primary epithelial infections, and reactivate in response to stress or sunlight. Previous studies have demonstrated that viral immediate-early protein ICP0 plays a key role in regulating the balance between lytic and latent infection. Recently, It has been determined that promyelocytic leukemia (PML) nuclear bodies (NBs), small ...[more]
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