Ontology highlight
ABSTRACT:
SUBMITTER: Luckoff A
PROVIDER: S-EPMC4888856 | biostudies-other | 2016 Jun
REPOSITORIES: biostudies-other
Lückoff Anika A Caramoy Albert A Scholz Rebecca R Prinz Marco M Kalinke Ulrich U Langmann Thomas T
EMBO molecular medicine 20160601 6
Age-related macular degeneration (AMD) is a leading cause of vision loss among the elderly. AMD pathogenesis involves chronic activation of the innate immune system including complement factors and microglia/macrophage reactivity in the retina. Here, we show that lack of interferon-β signaling in the retina accelerates mononuclear phagocyte reactivity and promotes choroidal neovascularization (CNV) in the laser model of neovascular AMD Complete deletion of interferon-α/β receptor (Ifnar) using I ...[more]