Unknown

Dataset Information

0

Oncogenic and oncosuppressive signal transduction at mitochondria-associated endoplasmic reticulum membranes.


ABSTRACT: The different mechanisms employed by proto-oncogenes and tumor suppressors to regulate cell death pathways are strictly linked to their localization. In addition to the canonical control of apoptosis at a transcriptional/nuclear level, intracellular zones are emerging as pivotal sites for the activities of several proapoptotic and antiapoptotic factors. Here, we review the function of the endoplasmic reticulum-mitochondria interface as a primary platform for decoding danger signals as well as a structural accommodation for several regulator or effector proteins.

SUBMITTER: Marchi S 

PROVIDER: S-EPMC4905193 | biostudies-other | 2014 Apr-Jun

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC2774047 | biostudies-literature
| S-EPMC2643492 | biostudies-literature
| S-EPMC7487091 | biostudies-literature
| S-EPMC8110587 | biostudies-literature
| S-EPMC8287518 | biostudies-literature
| S-EPMC3732980 | biostudies-literature
| S-EPMC10570331 | biostudies-literature
| S-EPMC10999572 | biostudies-literature
| S-EPMC8024009 | biostudies-literature
| S-EPMC8027129 | biostudies-literature