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Inhibitors of cell cycle checkpoints and DNA replication cause different responses in normal versus malignant urothelial cells.


ABSTRACT: S-phase checkpoints are triggered in tumor cells in response to DNA replication stress caused by the tumor microenvironment or oncogenes. A recent report from our laboratory showed that tumor cells and more normal epithelial cells have a very different response to replication stress. In this Author's View, the implications of this finding are discussed.

SUBMITTER: Meuth M 

PROVIDER: S-EPMC4905207 | biostudies-other | 2014 Oct-Dec

REPOSITORIES: biostudies-other

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