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Disrupting the endothelin and Wnt relationship to overcome chemoresistance.


ABSTRACT: Knowledge of the mechanisms underlying chemoresistance is important in the development of novel targeted treatments for ovarian cancer. We recently reported that targeting endothelin A receptor/β-arrestin-1, a binding partner of Wnt/β-catenin, is sufficient to sensitize ovarian cancer to chemotherapy. This result highlights endothelin-1 receptor antagonists as potential anticancer therapeutics.

SUBMITTER: Rosano L 

PROVIDER: S-EPMC4905315 | biostudies-other | 2015 Jul-Sep

REPOSITORIES: biostudies-other

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