Mitophagy and deubiquitination in yeast - the power of synthetic quantitative array technology.
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ABSTRACT: Use of synthetic quantitative array technology led to the identification of positive and negative modulators of rapamycin-induced mitophagy in yeast. The Ubp3-Bre5 deubiquitination complex was shown to inhibit mitophagy but promote other types of autophagy, including ribophagy. We propose an ubiquitin-dependent regulatory switch between different types of autophagy.
SUBMITTER: Behrendt C
PROVIDER: S-EPMC4905415 | biostudies-other | 2016 Mar
REPOSITORIES: biostudies-other
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