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Speed matters: How subtle changes in DNA end resection rate affect repair.


ABSTRACT: The contribution of BRCA1 (breast cancer 1) to the repair of broken DNA is well established, but its real role at the molecular level is less well understood. By developing a new high-resolution, single-molecule technique, we have now shown that BRCA1 accelerates the processing of DNA breaks that subsequently engage in homologous recombination.

SUBMITTER: Huertas P 

PROVIDER: S-EPMC4905430 | biostudies-other | 2015 Jul-Sep

REPOSITORIES: biostudies-other

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