Unknown

Dataset Information

0

?-arrestin-1 contributes to brown fat function and directly interacts with PPAR? and PPAR?.


ABSTRACT: The peroxisome proliferator-activated receptor (PPAR) family plays central roles in brown adipose tissue (BAT) adipogenesis and contributes to body temperature maintenance. The transcriptional activity of PPAR family has been shown to be tightly controlled by cellular signal networks. ?-arrestins function as major secondary messengers of G protein-coupled receptors (GPCR) signaling by functional interactions with diverse proteins. Here, we report that ?-arrestin-1 knock-out mice show enhanced cold tolerance. We found that ?-arrestin-1 directly interacts with PPAR? and PPAR? through a LXXXLXXXL motif, while D371 in PPAR? and L311/N312/D380 in PPAR? are required for their interactions with ?-arrestin-1. Further mechanistic studies showed that ?-arrestin-1 promotes PPAR?- but represses PPAR?-mediated transcriptional activities, providing potential regulatory pathway for BAT function.

SUBMITTER: Wang C 

PROVIDER: S-EPMC4908412 | biostudies-other | 2016

REPOSITORIES: biostudies-other

altmetric image

Publications

β-arrestin-1 contributes to brown fat function and directly interacts with PPARα and PPARγ.

Wang Congcong C   Zeng Xianglu X   Zhou Zhaocai Z   Zhao Jian J   Pei Gang G  

Scientific reports 20160615


The peroxisome proliferator-activated receptor (PPAR) family plays central roles in brown adipose tissue (BAT) adipogenesis and contributes to body temperature maintenance. The transcriptional activity of PPAR family has been shown to be tightly controlled by cellular signal networks. β-arrestins function as major secondary messengers of G protein-coupled receptors (GPCR) signaling by functional interactions with diverse proteins. Here, we report that β-arrestin-1 knock-out mice show enhanced co  ...[more]

Similar Datasets

| S-EPMC7274797 | biostudies-literature
| S-EPMC5885759 | biostudies-literature
| S-EPMC4916264 | biostudies-literature
| S-EPMC4544185 | biostudies-literature
2024-05-03 | GSE266292 | GEO
| S-EPMC4830884 | biostudies-other
| S-EPMC8533276 | biostudies-literature
| S-EPMC7663591 | biostudies-literature
| S-EPMC4066737 | biostudies-literature
| S-EPMC3244833 | biostudies-literature