Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC4908412 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Wang Congcong C Zeng Xianglu X Zhou Zhaocai Z Zhao Jian J Pei Gang G
Scientific reports 20160615
The peroxisome proliferator-activated receptor (PPAR) family plays central roles in brown adipose tissue (BAT) adipogenesis and contributes to body temperature maintenance. The transcriptional activity of PPAR family has been shown to be tightly controlled by cellular signal networks. β-arrestins function as major secondary messengers of G protein-coupled receptors (GPCR) signaling by functional interactions with diverse proteins. Here, we report that β-arrestin-1 knock-out mice show enhanced co ...[more]