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Unexpected oncosuppressive role for STAT3 in KRAS-induced lung tumorigenesis.


ABSTRACT: Signal transducer and activator of transcription 3 (STAT3) plays a critical role in the pathogenesis of several diseases and is considered a therapeutic target in solid cancers, including lung cancer. However, we recently demonstrated a tumor suppressive function of STAT3 in kirsten rat sarcoma oncogene homolog (KRAS)-driven lung cancer. Here, we discuss these findings and their consequences.

SUBMITTER: Grabner B 

PROVIDER: S-EPMC4909454 | biostudies-other | 2016 May

REPOSITORIES: biostudies-other

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