Ontology highlight
ABSTRACT:
SUBMITTER: Grabner B
PROVIDER: S-EPMC4366489 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Nature communications 20150303
STAT3 is considered to play an oncogenic role in several malignancies including lung cancer; consequently, targeting STAT3 is currently proposed as therapeutic intervention. Here we demonstrate that STAT3 plays an unexpected tumour-suppressive role in KRAS mutant lung adenocarcinoma (AC). Indeed, lung tissue-specific inactivation of Stat3 in mice results in increased Kras(G12D)-driven AC initiation and malignant progression leading to markedly reduced survival. Knockdown of STAT3 in xenografted ...[more]