Ontology highlight
ABSTRACT:
SUBMITTER: Acimovic J
PROVIDER: S-EPMC4917857 | biostudies-other | 2016 Jun
REPOSITORIES: biostudies-other
Ačimovič Jure J Goyal Sandeep S Košir Rok R Goličnik Marko M Perše Martina M Belič Ales A Urlep Žiga Ž Guengerich F Peter FP Rozman Damjana D
Scientific reports 20160623
Cholesterol synthesis is among the oldest metabolic pathways, consisting of the Bloch and Kandutch-Russell branches. Following lanosterol, sterols of both branches are proposed to be dedicated to cholesterol. We challenge this dogma by mathematical modeling and with experimental evidence. It was not possible to explain the sterol profile of testis in cAMP responsive element modulator tau (Crem τ) knockout mice with mathematical models based on textbook pathways of cholesterol synthesis. Our mode ...[more]