Ontology highlight
ABSTRACT:
SUBMITTER: McAlpine CS
PROVIDER: S-EPMC4922503 | biostudies-other | 2016 Jun
REPOSITORIES: biostudies-other
McAlpine Cameron S CS Swirski Filip K FK
Circulation research 20160601 1
Many aspects of human health and disease display daily rhythmicity. The brain's suprachiasmic nucleus, which interprets recurring external stimuli, and autonomous molecular networks in peripheral cells together, set our biological circadian clock. Disrupted or misaligned circadian rhythms promote multiple pathologies including chronic inflammatory and metabolic diseases such as atherosclerosis. Here, we discuss studies suggesting that circadian fluctuations in the vessel wall and in the circulat ...[more]