Ontology highlight
ABSTRACT:
SUBMITTER: Soares-Cunha C
PROVIDER: S-EPMC4931006 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Soares-Cunha Carina C Coimbra Barbara B David-Pereira Ana A Borges Sonia S Pinto Luisa L Costa Patricio P Sousa Nuno N Rodrigues Ana J AJ
Nature communications 20160623
Striatal dopamine receptor D1-expressing neurons have been classically associated with positive reinforcement and reward, whereas D2 neurons are associated with negative reinforcement and aversion. Here we demonstrate that the pattern of activation of D1 and D2 neurons in the nucleus accumbens (NAc) predicts motivational drive, and that optogenetic activation of either neuronal population enhances motivation in mice. Using a different approach in rats, we further show that activating NAc D2 neur ...[more]