Ontology highlight
ABSTRACT:
SUBMITTER: Reis FC
PROVIDER: S-EPMC4931827 | biostudies-other | 2016 Jun
REPOSITORIES: biostudies-other
Reis Felipe C G FC Branquinho Jéssica L O JL Brandão Bruna B BB Guerra Beatriz A BA Silva Ismael D ID Frontini Andrea A Thomou Thomas T Sartini Loris L Cinti Saverio S Kahn C Ronald CR Festuccia William T WT Kowaltowski Alicia J AJ Mori Marcelo A MA
Aging 20160601 6
Aging increases the risk of type 2 diabetes, and this can be prevented by dietary restriction (DR). We have previously shown that DR inhibits the downregulation of miRNAs and their processing enzymes - mainly Dicer - that occurs with aging in mouse white adipose tissue (WAT). Here we used fat-specific Dicer knockout mice (AdicerKO) to understand the contributions of adipose tissue Dicer to the metabolic effects of aging and DR. Metabolomic data uncovered a clear distinction between the serum met ...[more]