Ontology highlight
ABSTRACT:
SUBMITTER: Bersenev A
PROVIDER: S-EPMC3500428 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Bersenev Alexey A Rozenova Krasimira K Balcerek Joanna J Jiang Jing J Wu Chao C Tong Wei W
Aging cell 20120827 6
Upon aging, the number of hematopoietic stem cells (HSCs) in the bone marrow increases while their repopulation potential declines. Moreover, aged HSCs exhibit lineage bias in reconstitution experiments with an inclination toward myeloid at the expense of lymphoid potential. The adaptor protein Lnk is an important negative regulator of HSC homeostasis, as Lnk deficiency is associated with a 10-fold increase in HSC numbers in young mice. However, the age-related increase in functional HSC numbers ...[more]