Ontology highlight
ABSTRACT:
SUBMITTER: Papadopoulou T
PROVIDER: S-EPMC4934080 | biostudies-other | 2016 Jun
REPOSITORIES: biostudies-other
Papadopoulou Thaleia T Kaymak Aysegül A Sayols Sergi S Richly Holger H
Cell cycle (Georgetown, Tex.) 20160420 11
Mediator is considered an enhancer of RNA-Polymerase II dependent transcription but its function and regulation in pluripotent mouse embryonic stem cells (mESCs) remains unresolved. One means of controlling the function of Mediator is provided by the binding of the Cdk8 module (Med12, Cdk8, Ccnc and Med13) to the core Mediator. Here we report that Med12 operates together with PRC1 to silence key developmental genes in pluripotency. At the molecular level, while PRC1 represses genes it is also re ...[more]