Ontology highlight
ABSTRACT:
SUBMITTER: Vine KL
PROVIDER: S-EPMC4945850 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
Vine Kara L KL Belfiore Lisa L Jones Luke L Locke Julie M JM Wade Samantha S Minaei Elahe E Ranson Marie M
Heliyon 20160121 1
The search for novel anticancer therapeutics with the ability to overcome multi-drug resistance (MDR) mechanisms is of high priority. A class of molecules that show potential in overcoming MDR are the N-alkylated isatins. In particular 5,7-dibromo-N-alkylisatins are potent microtubule destabilizing agents that act to depolymerize microtubules, induce apoptosis and inhibit primary tumor growth in vivo. In this study we evaluated the ability of four dibrominated N-alkylisatin derivatives and the p ...[more]