Ontology highlight
ABSTRACT:
SUBMITTER: Hunyadi A
PROVIDER: S-EPMC6155823 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Hunyadi Attila A Csábi József J Martins Ana A Molnár Joseph J Balázs Attila A Tóth Gábor G
Molecules (Basel, Switzerland) 20170125 2
P-glycoprotein (P-gp, ABCB1) over-expression, causing a multi-drug resistant (MDR) phenotype, is a major problem in cancer chemotherapy that urgently requires novel approaches. Our previous studies showed certain ecdysteroid derivatives as promising chemo-sensitizers against MDR and non-MDR cancer cell lines while also exerting mild to moderate inhibition of P-gp function. Here we report the preparation of a set of substituted 2,3-dioxolane derivatives of poststerone, a known in vivo metabolite ...[more]