Ontology highlight
ABSTRACT:
SUBMITTER: Conley D
PROVIDER: S-EPMC4960614 | biostudies-other | 2016 Jul
REPOSITORIES: biostudies-other
Conley Dalton D Laidley Thomas M TM Boardman Jason D JD Domingue Benjamin W BW
Scientific reports 20160726
This study evaluates changes in genetic penetrance-defined as the association between an additive polygenic score and its associated phenotype-across birth cohorts. Situating our analysis within recent historical trends in the U.S., we show that, while height and BMI show increasing genotypic penetrance over the course of 20(th) Century, education and heart disease show declining genotypic effects. Meanwhile, we find genotypic penetrance to be historically stable with respect to depression. Our ...[more]