Ontology highlight
ABSTRACT:
SUBMITTER: Yim N
PROVIDER: S-EPMC4961865 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Yim Nambin N Ryu Seung-Wook SW Choi Kyungsun K Lee Kwang Ryeol KR Lee Seunghee S Choi Hojun H Kim Jeongjin J Shaker Mohammed R MR Sun Woong W Park Ji-Ho JH Kim Daesoo D Heo Won Do WD Choi Chulhee C
Nature communications 20160722
Nanoparticle-mediated delivery of functional macromolecules is a promising method for treating a variety of human diseases. Among nanoparticles, cell-derived exosomes have recently been highlighted as a new therapeutic strategy for the in vivo delivery of nucleotides and chemical drugs. Here we describe a new tool for intracellular delivery of target proteins, named 'exosomes for protein loading via optically reversible protein-protein interactions' (EXPLORs). By integrating a reversible protein ...[more]