Ontology highlight
ABSTRACT:
SUBMITTER: Tal-Gan Y
PROVIDER: S-EPMC4972187 | biostudies-other | 2016 Jul
REPOSITORIES: biostudies-other
Angewandte Chemie (International ed. in English) 20160608 31
Blocking quorum sensing (QS) pathways has attracted considerable interest as an approach to suppress virulence in bacterial pathogens. Toward this goal, we recently developed analogues of a native autoinducing peptide (AIP-III) signal that can inhibit AgrC-type QS receptors and attenuate virulence phenotypes in Staphylococcus aureus. Application of these compounds is limited, however, as they contain hydrolytically unstable thioester linkages and have only low aqueous solubilities. Herein, we re ...[more]