Ontology highlight
ABSTRACT:
SUBMITTER: Nielsen JB
PROVIDER: S-EPMC49732 | biostudies-other | 1992 Aug
REPOSITORIES: biostudies-other
Nielsen J B JB Foor F F Siekierka J J JJ Hsu M J MJ Ramadan N N Morin N N Shafiee A A Dahl A M AM Brizuela L L Chrebet G G
Proceedings of the National Academy of Sciences of the United States of America 19920801 16
The immunosuppressants FK506 and rapamycin prevent T-cell activation and also inhibit the growth of certain strains of the yeast Saccharomyces cerevisiae. It has previously been shown that yeast contains a 12-kDa cytosolic FK506-binding protein (yFKBP-12), which also possesses peptidylprolyl cis-trans isomerase activity, and that fkb1 strains lacking yFKBP-12 are resistant to rapamycin and sensitive to FK506. The absence of yFKBP-12 permitted the detection and isolation of a second FK506- and ra ...[more]