Ontology highlight
ABSTRACT:
SUBMITTER: Jin YJ
PROVIDER: S-EPMC52151 | biostudies-other | 1991 Aug
REPOSITORIES: biostudies-other
Jin Y J YJ Albers M W MW Lane W S WS Bierer B E BE Schreiber S L SL Burakoff S J SJ
Proceedings of the National Academy of Sciences of the United States of America 19910801 15
The 12-kDa FK506-binding protein (FKBP-12) is a cytosolic receptor for the immunosuppressants FK506 and rapamycin. Here we report the molecular cloning and subcellular localization of a 13-kDa FKBP (FKBP-13), which has a 21-amino acid signal peptide and appears to be membrane-associated. Although no internal hydrophobic region, and thus no transmembrane domain, is apparent within the 120 amino acids of mature FKBP-13, a potential endoplasmic reticulum retention sequence (Arg-Thr-Glu-Leu) is foun ...[more]