Ontology highlight
ABSTRACT:
SUBMITTER: Moraes-Vieira PM
PROVIDER: S-EPMC4973395 | biostudies-other | 2014 Mar
REPOSITORIES: biostudies-other
Moraes-Vieira Pedro M M PM Larocca Rafael A RA Bassi Enio J EJ Peron Jean Pierre S JP Andrade-Oliveira Vinícius V Wasinski Frederick F Araujo Ronaldo R Thornley Thomas T Quintana Francisco J FJ Basso Alexandre S AS Strom Terry B TB Câmara Niels O S NO
European journal of immunology 20140113 3
Leptin is an adipose-secreted hormone that plays an important role in both metabolism and immunity. Leptin has been shown to induce Th1-cell polarization and inhibit Th2-cell responses. Additionally, leptin induces Th17-cell responses, inhibits regulatory T (Treg) cells and modulates autoimmune diseases. Here, we investigated whether leptin mediates its activity on T cells by influencing dendritic cells (DCs) to promote Th17 and Treg-cell immune responses in mice. We observed that leptin deficie ...[more]