Ontology highlight
ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC4978450 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Wang Zhen Z Tran Misha C MC Bhatia Namrata J NJ Hsing Alexander W AW Chen Carol C LaRussa Marie F MF Fattakhov Ernst E Rashidi Vania V Jang Kyu Yun KY Choo Kevin J KJ Nie Xingju X Mathy Jonathan A JA Longaker Michael T MT Dauskardt Reinhold H RH Helms Jill A JA Yang George P GP
PloS one 20160809 8
<h4>Objective</h4>We identified significant expression of the matricellular protein, DEL1, in hypertrophic and mature cartilage during development. We hypothesized that this tissue-specific expression indicated a biological role for DEL1 in cartilage biology.<h4>Methods</h4>Del1 KO and WT mice had cartilage thickness evaluated by histomorphometry. Additional mice underwent medial meniscectomy to induce osteoarthritis, and were assayed at 1 week for apoptosis by TUNEL staining and at 8 weeks for ...[more]