Ontology highlight
ABSTRACT:
SUBMITTER: Ratner ES
PROVIDER: S-EPMC4984868 | biostudies-other | 2016 Mar
REPOSITORIES: biostudies-other
Ratner Elena S ES Zhu Yong-Lian YL Penketh Philip G PG Berenblum Julie J Whicker Margaret E ME Huang Pamela H PH Lee Yashang Y Ishiguro Kimiko K Zhu Rui R Sartorelli Alan C AC Lin Z Ping ZP
British journal of cancer 20160310 7
<h4>Background</h4>Platinum resistance may be attributable to inherent or acquired proficiency in homologous recombination repair (HRR) in epithelial ovarian cancer (EOC). The objective of this study was to evaluate the efficacy of the small molecule inhibitor triapine to disrupt HRR and sensitise BRCA wild-type EOC cells to platinum-based combination therapy in vitro and in vivo.<h4>Methods</h4>The sensitivity of BRCA wild-type cancer cells to olaparib, cisplatin, carboplatin, doxorubicin, or e ...[more]