Ontology highlight
ABSTRACT:
SUBMITTER: Wu S
PROVIDER: S-EPMC2754171 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Wu Su S Shi Yujiang Y Mulligan Peter P Gay Frédérique F Landry Joseph J Liu Huifei H Lu Ju J Qi Hank H HH Wang Weijia W Nickoloff Jac A JA Wu Carl C Shi Yang Y
Nature structural & molecular biology 20071118 12
DNA damage repair is crucial for the maintenance of genome integrity and cancer suppression. We found that loss of the mouse transcription factor YY1 resulted in polyploidy and chromatid aberrations, which are signatures of defects in homologous recombination. Further biochemical analyses identified a YY1 complex comprising components of the evolutionarily conserved INO80 chromatin-remodeling complex. Notably, RNA interference-mediated knockdown of YY1 and INO80 increased cellular sensitivity to ...[more]