Ontology highlight
ABSTRACT:
SUBMITTER: Godar M
PROVIDER: S-EPMC4992859 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Godar Marie M Morello Virginia V Sadi Ava A Hultberg Anna A De Jonge Natalie N Basilico Cristina C Hanssens Valérie V Saunders Michael M Lambrecht Bart N BN El Khattabi Mohamed M de Haard Hans H Michieli Paolo P Blanchetot Christophe C
Scientific reports 20160822
Bispecific antibodies are of great interest due to their ability to simultaneously bind and engage different antigens or epitopes. Nevertheless, it remains a challenge to assemble, produce and/or purify them. Here we present an innovative dual anti-idiotypic purification process, which provides pure bispecific antibodies with native immunoglobulin format. Using this approach, a biparatopic IgG1 antibody targeting two distinct, HGF-competing, non-overlapping epitopes on the extracellular region o ...[more]