Ontology highlight
ABSTRACT:
SUBMITTER: Verstovsek S
PROVIDER: S-EPMC4995084 | biostudies-other | 2016 Aug
REPOSITORIES: biostudies-other
The Journal of experimental medicine 20160801 9
Primary myelofibrosis (PMF) is a fatal neoplastic disease characterized by clonal myeloproliferation and progressive bone marrow (BM) fibrosis thought to be induced by mesenchymal stromal cells stimulated by overproduced growth factors. However, tissue fibrosis in other diseases is associated with monocyte-derived fibrocytes. Therefore, we sought to determine whether fibrocytes play a role in the induction of BM fibrosis in PMF. In this study, we show that BM from patients with PMF harbors an ab ...[more]