Ontology highlight
ABSTRACT:
SUBMITTER: Chen ZZ
PROVIDER: S-EPMC4999516 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Nature communications 20160824
Liver cancer has a tendency to develop asymptomatically in patients, so most patients are diagnosed at a later stage. Accumulating evidence implicates that liver tumour-initiating cells (TICs) as being responsible for liver cancer initiation and recurrence. However, the molecular mechanism of liver TIC self-renewal is poorly understood. Here we discover that a long noncoding RNA (lncRNA) termed LncSox4 is highly expressed in hepatocellular carcinoma (HCC) tissues and in liver TICs. We find that ...[more]