Ontology highlight
ABSTRACT:
SUBMITTER: Llopis-Hernandez V
PROVIDER: S-EPMC5001810 | biostudies-other | 2016 Aug
REPOSITORIES: biostudies-other
Llopis-Hernández Virginia V Cantini Marco M González-García Cristina C Cheng Zhe A ZA Yang Jingli J Tsimbouri Penelope M PM García Andrés J AJ Dalby Matthew J MJ Salmerón-Sánchez Manuel M
Science advances 20160826 8
Growth factors (GFs) are powerful signaling molecules with the potential to drive regenerative strategies, including bone repair and vascularization. However, GFs are typically delivered in soluble format at supraphysiological doses because of rapid clearance and limited therapeutic impact. These high doses have serious side effects and are expensive. Although it is well established that GF interactions with extracellular matrix proteins such as fibronectin control GF presentation and activity, ...[more]