Ontology highlight
ABSTRACT:
SUBMITTER: Narayan P
PROVIDER: S-EPMC5008674 | biostudies-other | 2016 Aug
REPOSITORIES: biostudies-other
Narayan Prakash P Duan Bin B Jiang Kai K Li Jingsong J Paka Latha L Yamin Michael A MA Friedman Scott L SL Weir Matthew R MR Goldberg Itzhak D ID
American journal of physiology. Renal physiology 20160601 2
Ischemia-reperfusion-mediated acute kidney injury can necessitate renal replacement therapy and is a major cause of morbidity and mortality. We have identified BB3, a small molecule, which when first administered at 24 h after renal ischemia in rats, improved survival, augmented urine output, and reduced the increase in serum creatinine and blood urea nitrogen. Compared with control kidneys, the kidneys of BB3-treated animals exhibited reduced levels of kidney injury molecule-1, neutrophil gelat ...[more]