Ontology highlight
ABSTRACT:
SUBMITTER: El-Masri H
PROVIDER: S-EPMC5009469 | biostudies-other | 2016 Jul
REPOSITORIES: biostudies-other
El-Masri Hisham H Kleinstreuer Nicole N Hines Ronald N RN Adams Linda L Tal Tamara T Isaacs Kristin K Wetmore Barbara A BA Tan Yu-Mei YM
Toxicological sciences : an official journal of the Society of Toxicology 20160504 1
A computational framework was developed to assist in screening and prioritizing chemicals based on their dosimetry, toxicity, and potential exposures. The overall strategy started with contextualizing chemical activity observed in high-throughput toxicity screening (HTS) by mapping these assays to biological events described in Adverse Outcome Pathways (AOPs). Next, in vitro to in vivo (IVIVE) extrapolation was used to convert an in vitro dose to an external exposure level, which was compared wi ...[more]