Ontology highlight
ABSTRACT:
SUBMITTER: Wolf DA
PROVIDER: S-EPMC5033865 | biostudies-other | 2016 Feb
REPOSITORIES: biostudies-other
Wolf Daniel A DA Hesterman Jacob Y JY Sullivan Jenna M JM Orcutt Kelly D KD Silva Matthew D MD Lobo Merryl M Wellman Tyler T Hoppin Jack J Verma Ajay A
JCI insight 20160225 2
The intrathecal (IT) dosing route offers a seemingly obvious solution for delivering drugs directly to the central nervous system. However, gaps in understanding drug molecule behavior within the anatomically and kinetically unique environment of the mammalian IT space have impeded the establishment of pharmacokinetic principles for optimizing regional drug exposure along the neuraxis. Here, we have utilized high-resolution single-photon emission tomography with X-ray computed tomography to stud ...[more]