Ontology highlight
ABSTRACT:
SUBMITTER: Kikuchi I
PROVIDER: S-EPMC5036006 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Kikuchi Ippei I Takahashi-Kanemitsu Atsushi A Sakiyama Natsuki N Tang Chao C Tang Pei-Jung PJ Noda Saori S Nakao Kazuki K Kassai Hidetoshi H Sato Toshiro T Aiba Atsu A Hatakeyama Masanori M
Nature communications 20160921
Evolutionally conserved Wnt, Hedgehog (Hh) and Notch morphogen pathways play essential roles in the development, homeostasis and pathogenesis of multicellular organisms. Nevertheless, mechanisms that intracellularly coordinate these signal inputs remain poorly understood. Here we found that parafibromin, a component of the PAF complex, competitively interacts with β-catenin and Gli1, thereby potentiating transactivation of Wnt- and Hh-target genes in a mutually exclusive manner. Parafibromin als ...[more]