Ontology highlight
ABSTRACT:
SUBMITTER: Mage MG
PROVIDER: S-EPMC50400 | biostudies-other | 1992 Nov
REPOSITORIES: biostudies-other
Mage M G MG Lee L L Ribaudo R K RK Corr M M Kozlowski S S McHugh L L Margulies D H DH
Proceedings of the National Academy of Sciences of the United States of America 19921101 22
Heterodimeric class I major histocompatibility complex molecules, which consist of a 45-kDa heavy-chain and a 12-kDa beta 2-microglobulin (beta 2m) light chain, bind endogenously synthesized peptides for presentation to antigen-specific T cells. We have synthesized a gene encoding a single-chain, soluble class I molecule derived from mouse H-2Dd, in which the carboxyl terminus of beta 2m is linked via a peptide spacer to the amino terminus of the heavy chain. The chimeric protein is secreted eff ...[more]