Ontology highlight
ABSTRACT:
SUBMITTER: Yuan W
PROVIDER: S-EPMC5045413 | biostudies-other | 2016 May
REPOSITORIES: biostudies-other
Yuan Wanqiong W Li Ting T Mo Xiaoning X Wang Xiaolin X Liu Baocai B Wang Wenyan W Su Yu Y Xu Lan L Han Wenling W
Oncotarget 20160501 20
CMTM3 (CKLF-like MARVEL transmembrane domain containing 3) possesses tumor suppressor properties in multiple types of malignancies. Restoration of CMTM3 significantly inhibits the metastasis of gastric cancer, and its expression level is correlated with prognosis. However, the physiological effects and the mechanism of CMTM3 remain unknown. Here, we suppress CMTM3 expression by shRNA to explore its endogenous effects and its mechanism of action in gastric cancer. Stable knockdown of CMTM3 promot ...[more]