Ontology highlight
ABSTRACT:
SUBMITTER: Bate-Eya LT
PROVIDER: S-EPMC5053701 | biostudies-other | 2016 May
REPOSITORIES: biostudies-other
Bate-Eya Laurel T LT den Hartog Ilona J M IJ van der Ploeg Ida I Schild Linda L Koster Jan J Santo Evan E EE Westerhout Ellen M EM Versteeg Rogier R Caron Huib N HN Molenaar Jan J JJ Dolman M Emmy M ME
Oncotarget 20160501 19
The anti-apoptotic protein B cell lymphoma/leukaemia 2 (BCL-2) is highly expressed in neuroblastoma and plays an important role in oncogenesis. In this study, the selective BCL-2 inhibitor ABT199 was tested in a panel of neuroblastoma cell lines with diverse expression levels of BCL-2 and other BCL-2 family proteins. ABT199 caused apoptosis more potently in neuroblastoma cell lines expressing high BCL-2 and BIM/BCL-2 complex levels than low expressing cell lines. Effects on cell viability correl ...[more]