Ontology highlight
ABSTRACT:
SUBMITTER: Yoshida N
PROVIDER: S-EPMC5056420 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Nature communications 20160929
Inducible cAMP early repressor (ICER) has been described as a transcriptional repressor isoform of the cAMP response element modulator (CREM). Here we report that ICER is predominantly expressed in Th17 cells through the IL-6-STAT3 pathway and binds to the Il17a promoter, where it facilitates the accumulation of the canonical enhancer RORγt. In vitro differentiation from naive ICER/CREM-deficient CD4<sup>+</sup> T cells to Th17 cells is impaired but can be rescued by forced overexpression of ICE ...[more]