Ontology highlight
ABSTRACT:
SUBMITTER: Shi F
PROVIDER: S-EPMC5058702 | biostudies-other | 2016 May
REPOSITORIES: biostudies-other
Oncotarget 20160501 21
NLRP12 is a member of the Nod-like receptor (NLR). Previous studies have reported enhanced colitis-associated inflammatory responses in NLRP12-deficient mice. In this study, we sought to investigate the role of NLRP12 in DSS-stimulated proinflammatory response in dendritic cells and mice colitis, and the molecular mechanisms involved in the development of the inflammation. Our results showed that down-regulation of NLRP12 is required for DSS-induced release of proinflammatory cytokines IL-1β and ...[more]