Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC5099859 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Scientific reports 20161108
B7-H1 (aka PD-L1) blocking antibodies have been used in treatment of human cancers through blocking B7-H1 expressed by tumor cells; however, their impact on B7-H1 expressing tumor-reactive CD8<sup>+</sup> T cells is still unknown. Here, we report that tumor-reactive CD8<sup>+</sup> T cells expressing B7-H1 are functional effector cells. In contrast to normal B7-H1 blocking antibody, B7-H1 antibodies capable of activating p38 MAPK lose their antitumor activity by deleting B7-H1<sup>+</sup> tumor- ...[more]